Damage resistances play a major role at Sigil as almost every race has some kind of it.
- Shapeshifters like wererats or werewolves have resistance to everything but alchemist silvered weapons.
- Fey are highly resistant to anything but cold iron weapons.
- Demons sometimes require cold iron weapons, but almost always require good aligned weapons.
- Skeletons are best harmed with blunt weapons. Other undead with Damage Resistance may be vulnerable to alchemist silvered weapons.
- Devils on the other hand are only vulnerable to good aligned or alchemist silvered weapons.
- Constructs are vulnerable to adamantine, as are spellcasters and shadowdancers using spells like stoneskin.